Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes

Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes

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Abstract Diabetes mellitus increases risk for tuberculosis disease and adverse outcomes.Most people with both conditions have type 2 diabetes, but it is unknown if type 1 and type 2 diabetes have identical effects on tuberculosis susceptibility.Here we show that male mice receiving a high-fat diet and streptozotocin here to model type 2 diabetes, have higher mortality, more lung pathology, and higher bacterial burden following Mycobacterium tuberculosis infection compared to mice treated with streptozotocin or high-fat diet alone.Type 2 diabetes model mice have elevated plasma glycerol, turbosound ts-18sw700/8a which is a preferred carbon source for M.tuberculosis.

Infection studies with glycerol kinase mutant M.tuberculosis reveal that glycerol utilization contributes to the susceptibility of the type 2 diabetes mice.Hyperglycemia impairs protective immunity against M.tuberculosis in both forms of diabetes, but our data show that elevated glycerol contributes to an additional adverse effect uniquely relevant to type 2 diabetes.